ANGPTL3 and hypertriglyceridemia: Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein known to inhibit lipoprotein lipase, the enzyme that degrades circulating triglycerides in the capillaries of muscle and adipose tissue, and its inhibition leads to hypertriglyceridemia, which enables atherosclerotic plaque formation [51].