CircCELF1 enhanced DKK2 expression by sponging miR-636, thereby inhibiting myocardial fibrosis progression in a mouse model of acute MI, and circRNA010567 inhibition improved cardiac function and alleviated myocardial fibrosis and apoptosis in a rat model of acute MI, constituting processes that seem to be mediated by the inhibition of the TGF-β1 signaling pathway [247,258]. This evidence concerns the gene DKK2 and Myocardial fibrosis.