Furthermore, circHelz in vivo essays demonstrated a regulation of the miR-133/NLRP3 (NLR family protein pyrin domain containing 3) axis (Figure 1), leading to low levels of NLRP3 inflammasome that, therefore, decreased myocardial infarct size, pyroptosis, and inflammation and increased cardiac function [81]. The gene discussed is NLRP3; the disease is myocardial infarction.