The most frequently used definition of iron deficiency (ID) in patients with cardiovascular disease is ferritin < 100 μg/L or ferritin 100–299 μg/L and transferrin saturation (TSAT) < 20% [6,7,8], however recent studies suggested that relying on ferritin for diagnosis of iron deficiency may be suboptimal [9,10]. This evidence concerns the gene TF and nutritional disorder.