PIK3C2A and chronic obstructive pulmonary disease: The animals in the SHAM group did not show VA, AVB, and LET; in addition, the serum levels of biochemical markers of cardiac injury in the SHAM group were lower when compared with the other groups, results that prove that the CIR protocol was able to promote both electrical alterations that were observed in the different forms of cardiac arrhythmias and cardiac injuries proven by serum increases in the markers of myocardial injury—CPK and CK-MB.