RYR2 and atrial fibrillation: Recent data in the literature also seem to correlate the mutation of the RYR2 gene with sinoatrial node and atrioventricular node dysfunction, atrial fibrillation [9] and with some overlap syndromes, such as left ventricular non-compaction and CPVT, in particular with deletion of exon 3 of the Ryr2 genes [3,4,10,11].