PCSK9 and familial hyperaldosteronism: FH is a common autosomal (prevalence of heterozygous FH [heFH] 1 in 250], dominantly inherited disorder of cholesterol metabolism caused by mutations in the LDL receptor (LDLR) gene, the apolipoprotein-B (apoB) gene or the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene.