Mutational profiling using a custom panel of 168 genes associated with aggressive B-cell lymphomas confirmed mutations in <i>ACTB</i>, <i>ARID1B</i>, <i>DUSP2</i>, <i>DTX1</i>, <i>HLA-B</i>, <i>PTEN</i>, and <i>TNFRSF14</i>. Here, ACTB is linked to B-cell non-Hodgkin lymphoma.