Several reports indicate that KDM4 family members are over-expressed in various cancers: KDM4A, KDM4B, and KDM4C are over-expressed in prostate cancer [74]; amplification of KDM4B is shown in medulloblastoma [77]; and KDM4C is required for the growth of breast carcinoma [78] and diffuse large B cell lymphoma [79]. Here, KDM4B is linked to Familial prostate cancer.