In a subanalysis of the ASTRONOMER study, which included 220 patients with mild to severe aortic valve stenosis, there was no difference in the rate of progression of aortic valve stenosis depending on the tertile levels of IgG and IgM autoantibodies to LDL modified with MDA-LDL and apoB-IC. The gene discussed is APOB; the disease is aortic valve stenosis.