Although BCL-6 is frequently rearranged in DLBCL, NOS of nodal and extranodal localization, Lima et al. [74] reported that BCL-6, as well as anaplastic lymphoma kinase (ALK), PAX5 and B-cell lymphoma 1 protein (BCL-1), also known as cyclin D1, genes were in a germline configuration, i.e., without rearrangements, in all 32 cases they examined. The gene discussed is CCND1; the disease is diffuse large B-cell lymphoma.