Pro-inflammatory cytokines, such as interleukin 6 (IL-6), interleukin 8 (IL-8), monokine induced by gamma (MIG), macrophage inflammatory protein-1β (MIP-1β), vascular endothelial growth factor (VEGF), interferon-gamma-inducible Protein 10 (IP-10), and monocyte chemoattractant protein-1 (MCP-1), are in higher levels in patients with osteoarthritis [16]. This evidence concerns the gene CCL2 and osteoarthritis.