The coexpression of high ERβ expression and AIB-1 and TIF-2 in MF in high-grade carcinoma with desmoplastic reaction and heavy lymphocytic infiltration suggests that the activation of AIB-1 and TIF-2 signal transductions in the MF may be involved in the initiation and progression of ERβ1-expressing BCa [65], as MF are the predominant cells in the cancer microenvironment that orchestrate the epithelial–mesenchymal crosstalk [66]. This evidence concerns the gene NCOA2 and carcinoma.