There is a relationship between IRS-1 and 2 and various types of cancer, such as breast [4,5,6,7,8], lung [9], prostate [10], hepatocarcinoma [11,12,13], neuroblastoma [14,15], head and neck [16], colorectal [17,18], esophageal squamous cell carcinoma [19], non-small cell lung cancer [20], and glioblastoma multiforme [21]. The gene discussed is IRS1; the disease is non-small cell lung carcinoma.