OCA2 and familial dilated cardiomyopathy: It has been shown by computer 3D simulations that the distribution of LTCC on the cell membrane is significantly different in normal cardiomyocytes, DCM and ICM, with LTCC present on the T-tubules in DCM and the protruding cell membrane surface LTCC changing to phosphorylated LTCC-P and activated by CaMKII in DCM cells, but LTCC-P in ICM is activated by PKA (Figure 1) [34].