Moreover, the protein obscurin, which is mainly expressed in the SR of cardiomyocytes, as well as its gene OBSCN, have been previously suggested to be structural proteins connecting the sarcomere M-line to the SR and to be implicated in striated muscle formation, and the OBSCN gene has been associated with hypertrophic cardiomyopathy. This evidence concerns the gene OBSCN and hypertrophic cardiomyopathy.