In a study on CPVT, it was mentioned that SK4 channel blockers protected calsequestrin 2 (CASQ2, the gene predisposing to CPVT), CASQ2-D307H KI and CASQ2 KO mice from deleterious polymorphic ventricular tachycardia (PMVT). This evidence concerns the gene CASQ2 and catecholaminergic polymorphic ventricular tachycardia.