In one study, whole exome sequencing (WES) of two cousins with confirmed ACM identified a new variant site in CDH2 (c.686A > C, p. Gln229Pro), and sequencing of suspected ARVC patients who were genetically negative also suggested the identification of an additional possible CDH2 variant (c.1219G > A, p. Asp407Asn) that could be causative. This evidence concerns the gene CDH2 and Arrhythmogenic right ventricular dysplasia.