The regions including switch I (residues 25–40) and switch II (residues 57–76) were considered as the pocket for the screening of suitable inhibitors in comparison with BI-2852 as the reference KRAS SI/II inhibitor [21].In the end, flavonoids are polyphenols that are highly reported for their anticancer potential against various cancers, such as lung, breast, colon, prostate, and ovarian [22]. Here, KRAS is linked to cancer.