PALB2 and pancreatic adenocarcinoma: In the pancreatic adenocarcinoma cases of the project GENIE, which included 5262 cases profiled, the most prevalent oncogenic or likely oncogenic mutations in DDR-related genes were in ATM and in BRCA2, followed by lower frequencies in BRCA1, PALB2, ATR and BRIP1 and a few cases in other genes (Table 2) [15].