Mihanfar et al. found a significant increase in the expression of AMP-activated kinase (AMPK) and SIRT1, and the related antioxidants catalase (CAT) and superoxide dismutase (SOD), as well as a decrease in the expression of CYP17A1, in a rat model of PCOS treated with fexarone. Here, SIRT1 is linked to polycystic ovary syndrome.