FOXO1 and primary ovarian failure: It has been shown that SIRT1 initiates the ROS scavenging pathway and maintains the normal function of granulosa cells, resists oxidative stress, maintains ovarian oxygen homeostasis, and plays a significant therapeutic role in PCOS and premature ovarian failure (POF) symptoms, mainly through the regulation of downstream proteins p53, FOXO1, FOXL2, CAT, and MnSOD.