STAT3 and familial pancreatic carcinoma: In a study [99] performed with 3D cultures of patient-derived pancreatic cancer cells, the administration of PG-S3-001 showed significant tumor growth inhibition and cell killing through its ability to potently bind (Kd = 324 nmol/L) to the STAT3 protein, thus decreasing its phosphorylation in pancreatic cancer cells.