STAT3 is a transcription factor that regulates stromal cell proliferation, viability, angiogenesis, metastases, and gemcitabine therapy resistance in pancreatic cancer, and several studies have shown that its inactivation can inhibit the survival and proliferation of human PDAC cells, making STAT3 a target of chemotherapeutic agents. Here, STAT3 is linked to familial pancreatic carcinoma.