STAT3-mediated tumorigenesis is associated with its ability to increase the levels of genes encoding antiapoptotic and proliferation-associated proteins (examples: Bcl-2, Bcl-xL, Mcl-1, Cyclin D1, and c-Myc), tumor angiogenesis inducers (VEGF and FGF), and tumor cell migration and invasion promoters (MMP-1, -2, -9, and -10) [141]. This evidence concerns the gene MMP1 and neoplasm.