The combined product of tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor–binding protein-7 (IGFBP-7), expressed as [TIMP-2] [IGFBP7], predicts the risk of AKI as well as the need for CKRT and death in critically ill adults [61,62]. Here, IGFBP7 is linked to acute kidney injury.