Therefore, several studies have been published in recent years where AI algorithms are challenged in increasingly specific classification tasks, such as differentiation within different subgroups of gliomas, for example, low-grade gliomas (LGGs) compared to high-grade gliomas (HGGs) [71,72]; isocitrate dehydrogenase (IDH) wild-type (IDH(−)) vs. IDH-mutated (IDH(−)) [73]; 1p/19q chromosomal arm deletion [74]; and others. The gene discussed is IDH1; the disease is central nervous system cancer.