Furthermore, some of the genes identified as upregulated in BRAF-mutated CRC patients were associated with detrimental outcomes, including HLA-DOA, CD74, HLA-DMB, and HLA-DQA1, further supporting the idea that the microenvironment of these tumors contributes to the development of an aggressive immunosuppressive phenotype. The gene discussed is HLA-DMB; the disease is colorectal carcinoma.