With ingenuity pathway analysis, the pathways that were enriched in the TMPRSS2‐overexpressing H1299 cells were determined and included coronavirus disease–COVID‐19, legionellosis, ribosome, influenza A, lipid and atherosclerosis, Yersinia infection, malaria, hedgehog signaling pathway, NOD‐like receptor signaling pathway, and pathogenic Escherichia coli infection (Fig EV4). The gene discussed is TMPRSS2; the disease is atherosclerosis.