For example, in AD, direct cell therapy with Tregs (Baek et al, 2016; Faridar et al, 2022; Yang et al, 2022) has given beneficial effects, although other studies have shown the reverse (Baruch et al, 2015; Yang et al, 2020), while treatment with IL2 has given conflicting results, depending on the AD model, ranging from protective (Baek et al, 2016; Alves et al, 2017) to minor (Dansokho et al, 2016) or no effect (preprint: Yshii et al, 2022a). The gene discussed is IL2; the disease is Alzheimer disease.