Transcriptomic analyses have permitted us to interrogate potential mechanism(s) of reserpine action in patient organoids and implicated signaling pathways involved in immune response (e.g. primary immunodeficiency, complement, and coagulation cascade), cell survival, and cell death (e.g. p53 signaling pathway, cellular senescence, apoptosis), metabolism (e.g. glutathione metabolism, purine metabolism), and proteostasis. Here, TP53 is linked to inborn error of immunity.