APP and neoplasm: Gene enrichment analysis (Xie et al., 2021) identified significant associations (adjusted p<0.05) between our gene candidates and macular thickness and degeneration, as seen in previous human GWAS studies (Buniello et al., 2019) and cataract formation (Elsevier pathway collection; Cheadle et al., 2017) as well as non-eye related diseases such as bone mineralization, tumor suppression, and Amyloid Precursor Protein pathways (Biocarta; Nishimura, 2001).