Additional significant candidates had previously identified functions that are not restricted to the eye but are still related to age, e.g. MEF2C being associated with Alzheimer’s disease (Xue et al., 2021) and multiple candidates (TSPAN11, NKX6-1, SLC16A1, RAET1G, SNTG1, ARRDC3, RASSF3, DIRC3, and GCNT3) associated with cancer (Supplementary file 8). The gene discussed is RASSF3; the disease is early-onset autosomal dominant Alzheimer disease.