GFAP and Creutzfeldt Jacob disease: Log(GFAP) and log(NfL) demonstrated sequentially incremental and statistically significant mean values between IPD-AR > 2 years and IPD-AR < 2 years, IPD and CJD cohorts on single-factor ANOVA with post hoc groupwise comparisons [Fig. 4A; log(GFAP), IPD-AR > 2 years versus IPD-AR < 2 years P = 0.0006, IPD-AR < 2 years versus healthy controls P = 0.0004, IPD-AR < 2 years versus IPD P = 0.0003; for log(NfL), IPD-AR > 2 years versus IPD-AR < 2 years P = 0.002, IPD-AR < 2 years versus healthy controls P = 0.002, and IPD-AR < 2 years versus IPD P = 3.7 × 10−6].