As for the iCJD-AR cohorts, relevant statistically significant mean values were only seen with log(GFAP) against the CJD cohort (2.01 versus 2.70 pg/ml; P = 0.02), and with log(Tau) against normal controls (0.609 versus 0.264 pg/ml; P = 0.03); the latter was driven by a single outlier in the sample obtained from an iCJD-AR individual with contemporaneous destructive pituitary craniopharyngioma. The gene discussed is GFAP; the disease is Creutzfeldt Jacob disease.