In addition, GWASs in different populations, including lean adults, lean adolescents, obese adults and obese adolescents, as well as subsequent replication analyses all identified that rs1387153 (in the 5′ region of MTNR1B) T allele was linked with elevated concentrations of fasting plasma glucose and glycosylated hemoglobin (HbA1c) as well as elevated T2DM risk [28,113]. Here, MTNR1B is linked to type 2 diabetes mellitus.