TCF7L2 and type 2 diabetes mellitus: A multiancestry genome-wide association study found four risk loci (MTNR1B, TCF7L2, CDKAL1, and CDKN2A-CDKN2B) for GDM, which were all linked with the risk of T2DM [190]; these findings also indicate that GDM and T2DM have shared pathophysiology.