ISAAC phase II estimated approximately 40% of asthma to be attributable to atopy (measured by allergen skin prick test reactivity [SPT] or presence of allergen‐specific IgE [sIgE]) among study centres from affluent countries but only 20% in non‐affluent countries, being approximately 11% in the two LA study centres in rural Ecuador and urban Brazil.16 This evidence concerns the gene IGHE and asthma.