IGHE and Autoimmunity: The presence of specific IgE antibodies against exogenous and endogenous antigens such as thyroid peroxidase, thyroglobulin, double‐stranded deoxyribonucleic acid (DNA), staphylococcal exotoxins or interleukin‐24 (Type I autoimmunity) or IgG autoantibodies against IgE or FcԑR1 (Type IIb autoimmunity) have been described in CSU patients19, 20, 21 and may induce degranulation of effector cells after crosslinking the FcԑRI.