AKT1 and neoplasm: Vascular endothelial growth factor A (VEGF-A) plays a vital role in angiogenesis regulation in normal and abnormal states, such as tumor angiogenesis [21]; AKT1 is a member of the serine/threonine AGC protein kinase family and is associated with cellular growth, metabolism, survival, and proliferation [22]; CXCL12 participates in a series of processes, such as inflammation and leukocyte trafficking, regulation of cell viability, and extracellular matrix remodeling [23].