BSG and cancer: To investigate the possibility that isolating circulating miRNAs by CD147 immunocapture might improve the diagnostic performance of a cancer‐associated miRNA, we assayed levels of miR‐210 in plasma samples of the same cohorts of healthy individuals and RCC patients as in Figure 7c and d When circulating miRNA was isolated by direct lysis, a significant difference in miR‐210 copy numbers was detected between healthy individuals and patients with advanced‐stage RCC but not between healthy individuals and patients with early‐stage RCC (Figure 8d).