Next, we examined the impact of knocking out LCN2 by generating myeloid-specific Lcn2 knockout (Lcn2f/fLysMcre) mice (Additional file 1: Fig. S6A) and inducing lung cancer cachexia in these mice and their control (Lcn2f/+LysMcre) littermates. The gene discussed is LCN2; the disease is lung cancer.