In addition, we observed aberrantly increased LCN2 (mRNA and protein) levels during cachexia progression in the eWAT, iWAT, and Gast of cachectic mice (Fig. 1K and Additional file 1: Fig. S1E), as well as stronger LCN2 protein signals (immunofluorescence staining) in the iWAT and Gast of cachectic mice (Additional file 1: Fig. S1C, D). Here, LCN2 is linked to Cachexia.