Immunohistochemistry and Western blot analysis showed that, compared with the WT-sham group, the levels of Synaptopodin, Nephrin, and CD2AP in WT-AKI-CKD and C3−/−-AKI-CKD groups were obviously decreased (P < 0.01), while TRPC6 increased considerably (P < 0.01). The gene discussed is CD2AP; the disease is acute kidney injury.