The results of TRPC6 immunohistochemistry showed that only a small amount of brown-yellow granules was present in the glomeruli of the WT-sham group and the C3−/−-sham group, on the other hand, a large amount in the WT-AKI-CKD group and a moderate amount in the C3−/−-AKI-CKD group (Fig. 2b). Here, TRPC6 is linked to chronic kidney disease.