PFKFB3 and diabetes mellitus: The representative images of PFKFB3 in benign breast tissues and breast invasive ductal carcinoma with/without diabetes were shown in Fig. 1A. The results showed that the expression level of PFKFB3 in non-diabetic invasive ductal carcinoma was higher than that in benign breast tissue (P < 0.001), while lower than that in diabetic invasive ductal carcinoma patients (P = 0.031) (Table 1).