Likewise, the association of PFKFB3 expression with clinicopathological parameters from breast cancer patients were analyzed with correlation analysis and the results showed that PFKFB3 expression was relevant to blood glucose level (P < 0.001), lymph node metastasis (P = 0.005), and tumor stage (P < 0.001) (Table 2). This evidence concerns the gene PFKFB3 and breast cancer.