PFKFB3 and breast cancer: The results of cellular proliferation experiment (Fig. 3A: cell counting assay; Fig. 3B: MTT assay; Fig. 3C: colony formation assay) showed that the mitotic ability, cell viability and the capacity to form colonies were significantly decreased after PFKFB3 knockdown in breast cancer cells; the results of cellular migration experiment (Fig. 3D: wound-healing assay and Fig. 3E: migration assay) showed that the migration ability of breast cancer cells was significantly decreased after PFKFB3 knockdown.