Since few studies have investigated the clinical effects of resveratrol on improving chronic periodontitis and inflammatory factors, this research aimed to evaluate the effect of resveratrol supplementation as an adjunct to non-surgical treatment of periodontal conditions, including pocket depth (PD), clinical attachment level (CAL), plaque index (PI), bleeding index (BI), and inflammatory factors, such as salivary levels of IL-8 and IL-1β. This evidence concerns the gene IL1B and chronic periodontitis.