CXCL8 and periodontitis: One of the main pathogens in the initiation of periodontitis, Porphyromonas gingivalis, stimulates proinflammatory cytokines such as IL-1β, IL-8, IL-6, and TNFα, which penetrate the gingival connective tissue, cause a local inflammatory response [2–4], and increase the number and activity of polymorphonucleocytes (PMNs), in association with the production of cytokines.