NOTCH1 and renal cell carcinoma: Since miRNA might have an ability to attenuate its target gene expression implicated in cancer development, it is suggestive that miRNA is an attractive natural product used for an alternative therapy [31–33]. Thus, the identification of the candidate miRNA(s) participated in NOTCH1-HES1 regulatory complex contributes to the better understanding of NOTCH1-induced RCC development.