NOTCH1 and renal cell carcinoma: Its uncontrolled expression is frequently observed in a variety of cancers such as RCC [25], indicating that miRNA might play a crucial role in the regulation of proliferation, differentiation, apoptosis and stress response of cancers [24, 26]. Indeed, it has been described that a variety of miRNAs including miR-19 [27], miR-21 [28] and miR-33a [29] are involved in the regulation of NOTCH1 signaling pathway [30].