ACE and obesity due to melanocortin 4 receptor deficiency: Fain et al. observed that most of the in vitro release of ACE-1 from adipose tissue was by stromal non-fat cells and more ACE-1 was released by omental adipose tissue (OAT) from patients with class III obesity > 40 kg/m2 (mean BMI 46 kg/m2) versus patients with class I obesity BMI 30–35 kg/m2 (mean BMI 32.9 kg/m2) [28].