Importantly, significant m6A-SNPs in well-known RA susceptibility genes were identified (Fig. 3), including rs2076595 in PADI2 (Fig. 4A); rs4836834 in TRAF1 (Fig. 5A); rs9985404 in PLCL2; rs9260149, rs1061235 rs79244404 and rs13488 in HLA-A; rs28367598, rs3177747, rs1057151, rs1056429 and rs709055 in HLA-B; and rs1042136, rs1042151 and rs9277410 in HLA-DPB1. Here, PLCL2 is linked to rheumatoid arthritis.