The pQTL analysis showed that seven RNAm-SNPs were associated with circulating levels of TFF3, including a m7G-SNP rs2263318 in HCP5 and six m6A-SNPs, rs1051790 in MICA, rs28366151 in PRRC2A, rs28367598 in HLA-B, rs3176007 in HLA-C, rs7774954 in HLA-DQB2 and rs9266689 in ZDHHC20P2. Meanwhile, circulating levels of TFF3 were associated with RA in our MR analyses. The gene discussed is HLA-B; the disease is rheumatoid arthritis.