ATP7A and Stroke: We were able to utilize exonic data from 177 genes from the initial set of 214 stroke loci panel (48) after removal of mitochondrial genes; non-exonic regions such as 9p.21 and non-coding RNAs, and genes that had poor quality control and quality assurance filtering data in the Saudi Genome Project control dataset including ATP7A, FLNA, GLA, GPR143, PGAM4, and F9. Focusing on the a priori 177 loci derived from the stroke panel, we identified rare putative impactful variants within the cohort (Supplementary Table S1).