As LPS shows a high abundance in primary CRC tissues,25 Song et al. designed an LPS-target fusion protein-coding sequence, which expressed an LPS trap protein after being loaded into a nanoparticle system in CRC tissue.25 Of note, LPS trap proteins prevented CRC liver metastasis in vivo.25 The tumor growth of LPS trap protein was inhibited even more pronounced after combining it with anti-PD-L1 therapy.25 Also, the LPS trap protein prolonged the survival time of CRC-bearing mice. Here, CD274 is linked to colorectal carcinoma.