Within the intestine, it can activate the NF-κB pathway by TLR4 receptors to aid the inflammatory response.21,22 This major inflammatory pathway not only aggravates gut barrier dysfunction but might also contribute to the onset and development of CRC.23 In addition, LPS seems to affect different steps of CRC metastasis, like cell adhesion to the extracellular matrix (ECM), cell detachment due to ECM degradation, and cell invasion.24 This evidence concerns the gene NFKB1 and colorectal carcinoma.