Another membrane receptor called tumor necrosis factor receptor 2 (TNFR2), associated with several different tumor entities, including CRC, promotes gut barrier disruption by deregulating the TJ proteins.28 Mechanistically, TNFR2 was found to upregulate the expression of the long isoform of myosin light chain kinase (MLCK) to impair TJs and disrupt the gut barrier. This evidence concerns the gene TNFRSF1B and colorectal carcinoma.