According to the analysis of 116 CRC patients, high expression of TLR-4 was associated with a high rate of metastasis and therefore related to poor prognosis.44 In vivo and in vitro assays also have proven that LPS promoted CRC cell adhesion and metastasis by mediating the TLR4 inflammatory signaling pathway.45,46. Here, TLR4 is linked to colorectal carcinoma.