We next investigated whether the transcriptional profile of pMHCII-NP-induced TR1-like cells might be influenced by genetic background (NOD vs. C57BL/6), MHC class II allele type (I-Ag7 vs. I-Ab) or the nature of the underlying inflammatory process responsible for endogenous T-cell priming (T1D vs. colitis). The gene discussed is HLA-C; the disease is colitis.