Likewise, the bulk splenic CD4+ T cells and the tetramer+ CD4+ T cells from BDC2.5 mi/I-Ag7-NP-treated donors (but not the splenic CD4+ T cells from untreated donors or the tetramer– cells from pMHCII-NP-treated mice) efficiently suppressed diabetes development in T-cell-reconstituted NOD.Scid hosts [11]. This evidence concerns the gene CD4 and diabetes mellitus.