HLA-C and type 1 diabetes mellitus: We next investigated whether the transcriptional profile of pMHCII-NP-induced TR1-like cells might be influenced by genetic background (NOD vs. C57BL/6), MHC class II allele type (I-Ag7 vs. I-Ab) or the nature of the underlying inflammatory process responsible for endogenous T-cell priming (T1D vs. colitis).