HK2 and hematoma: The combination of metabolic and protein data (increased levels of glycolytic, TCA cycle and mitochondrial/oxidative phosphorylation proteins) complemented by gene expression analysis (higher levels of hexokinase 2 indicating increased shuttling of glucose into the CCM), gave us reason to assume that an enhanced cellular metabolism occurs across the complex hematoma and early callus tissue in successful healing (high anabolic demand) compared to compromised bone healing.