Besides, TEDC2 expression was also correlated with TNFRSF25, TNFRSF4 and TNFRSF18 in our analysis, which might be correlated with immune evasion and poor outcome in lung cancer, but the molecular mechanisms of these immune checkpoint molecules still remain elusive and need further investigation30,31. The gene discussed is TNFRSF4; the disease is lung carcinoma.