First, Padi4 knockout produced fewer metastatic nodules in orthotopic tumor models of 4T1, even when 4T1 primary tumor size was matched (Fig. 3f and Extended Data Fig. 5a–c) and EO771-LMB, with no difference in EO771 primary tumor size (Fig. 3g and Extended Data Fig. 5d,e). The gene discussed is PADI4; the disease is neoplasm.