We further tested canonical apoptosis inducers BH3-mimetics such as navitoclax and venetoclax (BCL-2 inhibitors), as well as S63845 (MCL-1 inhibitor) and found both robust nuclear bursting and calcium spike in 4T1 tumor cells (Extended Data Fig. 3e,f and Supplementary Video 8). This evidence concerns the gene BCL2 and neoplasm.