As a mirror of TGFβ− regulation of FOXP3 in Treg cells, TGFβ1-treated CLL B cells showed increased FOXP3 levels while IL10 treatment did not reach significant increase (Fig. 5C), further arguing for different roles between TGFβ1 and IL10. This evidence concerns the gene FOXP3 and B-cell chronic lymphocytic leukemia.