At present, CLL-B cells are considered antigen-experienced B cells with an IGHV mutational status, being either a T-dependent (mutated IGHV, M-IGHV) or T-independent (unmutated IGHV, UM-IGHV) memory phenotype with both subsets expressing CD27 [1]. The gene discussed is CD27; the disease is B-cell chronic lymphocytic leukemia.