CD81 and neoplasm: In our CLL cohort, CD5+CD19+CD27+ cells represented the discriminant phenotypic features of IL10+vs- and TGFβ1+vs- subsets, which also resembled CD19+CD81+CD27+CD25+PD-L1hi tumor evoked Bregs producing both IL10 and TGFβ1 in sarcomas [49].