BACE2 and early-onset autosomal dominant Alzheimer disease: Gene-based association (Supplementary Table 1) yielded two suggestive gene signals; one for TRPM6 on chromosome 9 (minimum p = 2.31 × 10−6), which encodes a magnesium channel protein39,40, and another for BACE2 on chromosome 21 (minimum p = 3.08 × 10−6) which codes for an essential enzyme for the cleavage of β-Amyloid and the development of Alzheimer’s disease (AD)41–43.