Knockdown of SVIL led to YTHDF2 downregulation in LFS astrocytes and in GBM cells expressing mutant p53 (LNZ308-p53(G245D)) but not in WT astrocytes and in LNZ308-Vector cells (Fig. 3k and Supplementary Fig. 4h, i). The gene discussed is SVIL; the disease is glioblastoma.