The m6A-marked CDKN2B and SPOCK2 transcripts were negatively regulated by mutant p53/SVIL/MLL1-regulated YTHDF2 in LFS astrocytes (Fig. 5g, h, k, l), suggesting that suppression of CDNK2B and SPOCK2 may promote tumor initiation. This evidence concerns the gene CDKN2B and neoplasm.