To examine whether the mutant p53-rewired YTHDF2-associated m6A epitranscriptomic networks contribute to mutant p53 gain-of-function toward glioma progression in vivo, we investigated the role of the mutant p53/SVIL/MLL1/YTHDF2 axis in LNZ308-p53(G245D) tumorigenesis. The gene discussed is KMT2A; the disease is central nervous system cancer.