Here we report that Rit2 reduces phosphorylation levels of S1292-LRRK2 in recombinant neuroblastoma cells (Fig. 4c, d) and is neuroprotective in animals with no LRRK2 mutations (Fig. 5), therefore we assessed the impact of Rit2 on S1292 autophosphorylation in the mouse DA neurons. Here, RIT2 is linked to neuroblastoma.