While previous studies based on human cells and mouse models showed cancer-cell-intrinsic inflammation was mainly caused by mutations in driver genes66,72–74, here we did not find any significant association between harboring top inflammatory tumor cluster and sample-level mutation in established ccRCC driver genes, such as VHL, BAP1, PBRM1, or SETD2 (P > 0.3). This evidence concerns the gene SETD2 and nonpapillary renal cell carcinoma.