PDCD1LG2 and neoplasm: Surveying the microenvironment of tumors with cancer-cell-intrinsic inflammatory tumor clusters, we observed a moderate association between tumor-cluster inflammatory score and macrophage content (R = 0.41, FDR = 0.11) and a significant upregulation of PDL2 (PDCD1LG2; log2FC = 0.19) in tumors with top inflammatory scores (Fig. 4i).