We further identified 16 TF motifs that are most consistently enriched in tumor cells, including HIF1A/ARNT, NF-κB TFs (NFKB1, NFKB2, REL, RELA), RBPJ, MXI1, KLF9, ZNF75D, HSF2, NEUROD1, SREBF2, NEUROG2, RREB1, and TBXT (Fig. 3a). This evidence concerns the gene REL and neoplasm.