For example, in colorectal cancer (CRC), β-catenin and YAP1 complementarily play critical roles on renewal and differentiation of mesenchymal stem cells, proliferation potential are the cooperative function of YAP1 and HOXB3 that isn’t shared by β-catenin, while all of them contribute to cells’ migration and invasion [6, 23, 41, 44]. Here, YAP1 is linked to colorectal cancer.