HOXB3 and neoplasm: To research the function of HOXB3 activation in APC-suppressed tumors (one type of WNT-ON tumor), we introduced a doxycycline-inducible shRNA targeting HOXB3 (Tet-off) into the LNCaP-AI cells with APC knockdown (LAPCi-HOXB3Tet for short).